Synthetic tetrapeptide research compound for neuroendocrine and cellular-pathway studies.
- Dose
- 10 mg
- Batch
- 268006
Epitalon
L-Alanyl-L-glutamyl-L-aspartyl-glycine (AEDG tetrapeptide; epithalon) · AEDG
For research purposes only — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Synthetic tetrapeptide research compound for neuroendocrine and cellular-pathway studies.
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- Lab
- Freedom Diagnostics
- Purity
- 99.22%
- Methods
- HPLC-UV · LC-MS
- Tested
- Sep 21, 2026
For laboratory research use only. Not for human consumption.
Technical specifications
- Type
- Peptide
- Scientific name
- L-Alanyl-L-glutamyl-L-aspartyl-glycine (AEDG tetrapeptide; epithalon)
- Amino acids
- 4
- Sequence
- AEDG
- Molecular weight
- 390.35 g/mol
- Formula
- C14H22N4O9
- CAS
- 307297-39-8
- Origin
- Synthetic tetrapeptide modeled on the amino-acid composition of epithalamin, a bovine pineal gland extract; AEDG was later identified directly within the native pineal polypeptide complex.
- Lyophilized (powder)
- -20°C · stable long-term; -80°C for multi-year storage. Keep sealed and desiccated, protected from light.
- Reconstituted
- 2-8°C · use within 30 days. Aliquot to avoid repeated freeze-thaw cycles.
- Room temperature
- Lyophilized powder tolerates short ambient excursions in transit, but sustained room-temperature storage accelerates hydrolysis and deamidation of the Asp-Gly bond; solutions in particular should not be held at room temperature.
Peer-reviewed research
Published research and registered trials involving this compound. Provided for educational reference only — none of it is a claim about this product.
- Bulletin of Experimental Biology and MedicineEpithalon peptide induces telomerase activity and telomere elongation in human somatic cellsKhavinson VKh, Bondarev IE, Butyugov AA2003DOI: 10.1023/a:1025493705728PMID: 12937682
- International Journal of CancerInhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic miceAnisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C2002DOI: 10.1002/ijc.10570PMID: 12209581
- Bulletin of Experimental Biology and MedicineEffect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimesVinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN2007DOI: 10.1007/s10517-007-0441-zPMID: 18856211
- Bulletin of Experimental Biology and MedicineIdentification of Peptide AEDG in the Polypeptide Complex of the Pineal GlandKhavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS2017DOI: 10.1007/s10517-017-3922-8PMID: 29124531
- MoleculesAEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic MechanismKhavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B2020DOI: 10.3390/molecules25030609PMID: 32019204
- BiogerontologyEpitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityAl-Dulaimi S, Thomas R, Matta S, Roberts T2025DOI: 10.1007/s10522-025-10315-xPMID: 40908429
- International Journal of Molecular SciencesOverview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising PropertiesAraj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł2025DOI: 10.3390/ijms26062691PMID: 40141333
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